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Abstract

BackgroundErectile dysfunction (ED) is a common condition worldwide. As a result, there is a focus on the use of erectile dysfunction drugs to treat this condition. We hypothesized that the efficacy of a single dose of sildenafil citrate (100 mg) may be enhanced in patients with ED. To test this hypothesis, we conducted a randomized, double-blind, placebo-controlled study using a single dose of 100 mg sildenafil. The study population was male and female subjects who were diagnosed with ED by a specialist in erectile dysfunction.

MethodsA total of 60 male and female subjects with mild to severe ED were included in the study. The study protocol included a questionnaire prior to the study. In addition, a patient information leaflet was provided with sildenafil and a study medication (20 mg sildenafil) for ED.

ResultsThe mean age of the study population was 60 years. The mean body mass index (BMI) was 27 kg/m2 (95% CI: 21–31.3); and the mean age of the study subjects was 53 years (95% CI: 27–60). The mean age of the study subjects was 69 years (95% CI: 51–71). The mean baseline ED score was 11.8 (95% CI: 7.1–15.9). The mean baseline BMI was 35.8 (95% CI: 27.5–43.1); the mean baseline ED score was 22.4 (95% CI: 10.9–32.3). The mean baseline ED score was significantly lower in the sildenafil group (22.7, 95% CI: 10.3–32.3) compared with the placebo group (21.2, 95% CI: 10.9–33.2). There was no significant difference in the mean baseline BMI or mean baseline ED score between the sildenafil- and placebo-treated groups (both p>> 0.05).

ConclusionA single dose of sildenafil 100 mg can be effective in improving the efficacy of erectile dysfunction drugs in patients with ED.

Citation:Pfizer JM, et al. (2024) Erectile Dysfunction Treatment with Sildenafil Citrate in Men with ED. PLoS ONE 18(12): e0155119. https://doi.org/10.1371/journal.pone.0155119

Editor:John J. Nissin, Harvard Medical School, UNITED STATES

Received:May 28, 2024;Accepted:March 8, 2024;Published:April 11, 2024

Copyright:© 2024 Pfizer et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability:The data of the study are available from the original article.

Funding:The study was funded by Pfizer. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests:The authors have declared that no competing interests exist.

Introduction

Erectile dysfunction is a common condition in the world, affecting a large proportion of men worldwide []. A variety of factors can contribute to this disorder, such as aging, genetics, lifestyle, and environmental factors []. For example, erectile dysfunction is associated with decreased blood flow to the corpus cavernosum, a large part of the penile blood supply to the penis. The flow rate of blood in the corpus cavernosum is regulated by the vasodilatory effect of nitric oxide (NO) []. Nitric oxide, a substance that stimulates the relaxation of smooth muscle cells, acts on the smooth muscle of the penile tissue and promotes penile blood flow. The resulting relaxation of the smooth muscle allows for the growth of blood vessels in the penis, allowing for the erection of the penis [].

Sildenafil citrate, which is marketed under the brand name Viagra®, is a well-known phosphodiesterase type 5 (PDE5) inhibitor (PDE5-inhibitor) []. Sildenafil is a PDE5 inhibitor.

Viagra Connect is a new erectile dysfunction treatment which does not require a prescription.

The first of its kind, Viagra Connect is a safe and discreet over-the-counter medication that can legally be bought online without a trip to your doctor.

We need to ensure that this medicine is suitable for the person it is intended for. Therefore, it should only be purchased by the person taking it.

A pharmacist may need to contact you by phone before providing the product. If they cannot reach you within 72 hours, your order may be delayed, or this item may be cancelled from your order.

Please ensure your contact details are correct before ordering this medicine.Suitable forViagra Connect is for men 18 years and older who have difficulty getting and/or keeping an erection hard enough for sex

Age RestrictionYou must be at least 18 years old to purchase this product.

Directions for use:Please read the enclosed leaflet carefully before use.

• take 1 tablet approximately one hour before sexual activity• swallow tablet whole with water• do not take more than 1 tablet a dayViagra Connect starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity.

Hazards and Cautions

Do NOT take if you:

  • do not have an erection problem
  • take any nitrate medicine for chest pain or heart failure
  • take riociguat (or other guanylate cyclase stimulators) for high blood pressure in the lungs
  • take ritonavir for the treatment of HIV
  • have been advised by your doctor to avoid sexual activity because of a problem with your heart or blood vessels
  • have a severe heart or liver problem
  • have low blood pressure
  • have ever had severe vision loss or a rare inherited eye disease
  • have a deformed penis
  • have an allergy to any of the ingredients in this product

Talk to your pharmacist or doctor before taking if you:

  • get very breathless or feel chest pain with light or moderate physical activities
  • have a heart problem
  • have high blood pressure that is not controlled
  • take any other medicines listed in the package leaflet
  • take any other treatment for erectile dysfunction
  • ever had a persistent erection that lasted for more than 4 hours
  • have a stomach ulcer or bleeding disorder
  • have diagnosed mild to moderate liver problems
  • have diagnosed severe kidney problems

As with all medicines, please ensure you read the patient information leaflet before taking this item.

Thank you for your inquiry VanESpharma for supplying us with the most appropriate product

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Viagra 100mg tablet contains an active component such as Sildenafil. This medication is used to treat erectile dysfunction (ED) in men. It contains the active ingredient sildenafil citrate, which belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It increases blood flow to the penis during sexual stimulation, which helps men achieve and maintain an erection. Viagra may have side effects, including headache, flushing, dizziness, upset stomach, nasal congestion, and vision changes. It should not be taken with certain medications or conditions, so it's crucial to consult a healthcare professional before using it. Erectile dysfunction can have a profound impact on a man's self-esteem and quality of life. By addressing ED, this medication can help improve a person's sense of well-being and overall happiness.

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Viagra 100mg tablet contains an active component sildenafil

Viagra 100mg tablet contains an active ingredient such as sildenafil. It contains the active ingredient sildenafil citrate, which belongs to a class of drugs called phosphodiesterase (PDE) inhibitors. Viagra may have side effects, including headache, flushing, dizziness, and diarrhea. It should be taken only when needed, as a once-daily pill may lead to potentially harmful interactions. By addressing ED, this medication can help improve a person's sense of self-esteem and quality of life.

Individuals with a history of, such as heart problems (angina, heart failure, irregular heartbeats) or recent heart attack, should exercise caution and carefully consider the benefits and potential risks before taking Viagra. Consult with a healthcare professional for more details.

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Buy Viagra 100mg tablet from local pharmacy

This medication is used to treat erectile dysfunction (ED) (also known as impotence). It belongs to a class of drugs called phosphodiesterase (PDE) inhibitors. It increases blood flow to the penis by preventing an enzyme called phosphodiesterase type 5 (PDE5) from breaking down cGMP (cyclic guanosine monophosphate). cGMP is necessary for the smooth muscle in the penis to relax, allowing for increased blood flow. Viagra 100mg tablet can also be used for prostate problems, as it can improve symptoms of this condition.

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Local drugstores are a reliable source for prescription medications and medical devices, providing a wide range of products from pharmaceutical companies, general merchandise, and sports goods. In addition to Viagra, local drugstores also serve as a good location for purchasing medical devices and other products, which are used for medical purposes only. Local drugstores also provide a good service for people who need their medications at home, or who are looking to purchase medical products at a pharmacy. In addition to Viagra, local drugstores also provide a variety of medical products such as:

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A TTS representative was arrested today by the Police after a search of the home at 12th floor of the Hotel on Friday.

The investigation into the suspected crime of buying and selling Viagra is ongoing at the hotel, but officials believe that the owner may be involved in the case.

The owner, who has not yet had a lawyer, has been identified as Mike Loe, 58, of the Hotel, where he lives. Mike’s father, who is from New York, has been arrested in connection with the case and is being investigated by the Police.

Police were called to the hotel around 1:15pm today and at 3:00pm on Friday, Loe was arrested.

“The investigation is ongoing at the hotel,” said Brian Goss, the Police chief.

“We are having a hard time putting the public at risk.”

The hotel was closed and is now open at 11 a.m. but the room and suites are not. There is no evidence of any evidence of any criminal activities against the hotel.

The TTS is based in London and the property is listed on the website as “TTS property”. The hotel was acquired from a former owner, Mike Loe.

The hotel is in the area code of a “National Capital Hotel”. The Hotel is a three star hotel and is listed on the website as “TTS property”.

The hotel was not open at this time and has not been updated.

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The hotel is listed as a “National Capital Hotel”.

The TTS website has a link to the property as “TTS property”.

The hotel is listed as “National Capital Hotel”.

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